塑化劑打趴了精蟲品質

2018 年 7 月 19 日陳啟煌

塑化劑風暴何時平息？如滾雪球不見停損

· 2011-06-01

· 中廣新聞／林麗玉

塑化劑風暴從5月下旬持續延燒，遭波及的食品有如滾雪球越滾越大，從最早的運動飲料、一路波及水果口味加工品、水果飲料、茶飲、果漿、果凍、果醬等，連還有民眾常吃的保健食品膠囊錠粉狀食品，也都有許多知名廠商遭波及。而衛生署訂定5月31號為終止黑心起雲劑的D-day，從31號凌晨零點開始，五大類食品，包括「運動飲料」、「果汁飲料」、「茶飲料」、「果醬、果漿或果凍」、「膠囊錠狀粉狀」等食品，如果沒有食品安全證明，一律不得在架上販售，而D-day大限到期的首波稽查，許多超商、超市、賣店，根本還搞不清楚如何陳列食品安全證明，許多超商、超市等，就將許多商品品項的食品安全證明放置成一大疊，遭衛生單位開立限改單，光是以台北市為例，首波稽查，就稽查數千件商品，因為無法提出安全證明，立即被要求下架，要等補齊資料之後，才能再上架販售。

生育與絕育。 2011年5月28日搶鮮版。

(本土的研究上了國際生殖頂尖期刊)

標題

暴露在聚氯乙烯丸(PVC)工廠空氣中的工人其塑化物二（2乙基己基）鄰苯二甲酸酯（DEHP塑化物）濃度與精液質量的關係

高雄國立高雄第一科技大學，嘉義崇仁護理學院

摘要

目的：探討暴露在聚氯乙烯丸(PVC)工廠空氣中的工人其塑化物二（2乙基己基）鄰苯二甲酸酯（DEHP塑化物）濃度與精液質量的關係

設計：橫斷面研究。

地點：台灣聚氯乙烯工廠。

患者：受聘於兩個聚氯乙烯粒料廠的四十五位男性工人。

研究係數（補）：無。主要結果測量（補）：精子濃度，活動力，形態和染色質 DNA完整性進行訪問。

結果：工人分為低和高DEHP的暴露組按照DEHP的平均水平（23.7微克/立方米（3））的個人空氣。在高DEHP的暴露組，顯著上升趨勢中找到精子DNA變性（αT）誘導，DNA片段化指數（DFI），能夠飲用咖啡傾向。調整後喝咖啡，吸煙，年齡，個人空氣中DEHP的濃度呈正協會與αT（β= 0.038）和DFI（β= 0.140），並與精子活力呈負相關（β= -0.227）。

結論：這是首次研究證明周圍的空氣中DEHP的濃度和不利影響精子活力和染色質 DNA完整性之間有關聯。鑑於目前廣泛使用這些 PVC製品，其意義為鄰苯二甲酸鹽的毒性和職業健康也有相當大的影響。

原文

Fertil Steril. 2011 May 28. [Epub ahead of print]

The association between semen quality in workers and the concentration of di(2-ethylhexyl) phthalate in polyvinyl chloride pellet plant air.

Huang LP, Lee CC, Hsu PC, Shih TS.

Source

Department of Safety, Health and Environmental Engineering, National Kaohsiung First University of Science and Technology, Kaohsiung, Taiwan; Department of Nursing, Chung-Jen College of Nursing, Health Sciences and Management, Chiayi, Taiwan.

Abstract

OBJECTIVE:

To investigate potential associations between semen quality in workers and the concentrations of di(2-ethylhexyl) phthalate (DEHP) in personal air collected from polyvinyl chloride (PVC) plants.

DESIGN:

Cross-sectional study.

SETTING:

PVC plants in Taiwan.

PATIENT(S):

Forty-five male workers employed in two PVC pellet plants.

INTERVENTION(S):

None. MAIN OUTCOME MEASUREMENT(S): Sperm concentration, motility, morphology, and chromatin DNA integrity were accessed.

RESULT(S):

The workers were divided into low- and high-DEHP-exposed groups in accordance with the median levels of DEHP (23.7 μg/m(3)) in personal air. In the high-DEHP-exposed group, significant increases were found in the tendency for sperm DNA denaturation (αT) induction, the DNA fragmentation index (DFI), and propensity for coffee drinking. After adjusting for coffee drinking, cigarette smoking, and age, personal air concentrations of DEHP showed positive associations with αT (β = 0.038) and DFI (β = 0.140) and negative associations with sperm motility (β = -0.227).

CONCLUSION(S):

This is the first study to demonstrate a link between DEHP concentration in ambient air and the adverse effects in sperm motility and chromatin DNA integrity. Given the current wide use of these PVC products, the implications for phthalates toxicity and occupational health could be considerable.