{"id":1230,"date":"2018-07-19T18:45:22","date_gmt":"2018-07-19T10:45:22","guid":{"rendered":"http:\/\/baopie.doctor.binflux.com\/2018\/07\/19\/d5-d6%e7%9a%84%e5%9b%8a%e8%83%9a%e6%a4%8d%e5%85%a5%e8%bc%83%e7%ac%ac3%e5%a4%a9%e8%83%9a%e8%83%8e%e7%a7%bb%e6%a4%8d%e5%be%8c%e5%96%ae%e8%83%8e%e5%a6%8a%e5%a8%a0%e6%97%a9%e7%94%a2%e7%9a%84%e9%a2%a8\/"},"modified":"2018-07-19T18:45:22","modified_gmt":"2018-07-19T10:45:22","slug":"d5-d6%e7%9a%84%e5%9b%8a%e8%83%9a%e6%a4%8d%e5%85%a5%e8%bc%83%e7%ac%ac3%e5%a4%a9%e8%83%9a%e8%83%8e%e7%a7%bb%e6%a4%8d%e5%be%8c%e5%96%ae%e8%83%8e%e5%a6%8a%e5%a8%a0%e6%97%a9%e7%94%a2%e7%9a%84%e9%a2%a8","status":"publish","type":"post","link":"https:\/\/www.becphd.pro\/?p=1230","title":{"rendered":"D5& D6\u7684\u56ca\u80da\u690d\u5165\u8f03\u7b2c3\u5929\u80da\u80ce\u79fb\u690d\u5f8c\u55ae\u80ce\u598a\u5a20\u65e9\u7522\u7684\u98a8\u96aa\u589e\u52a0"},"content":{"rendered":"

\u00a0D3 \u7684\u80da\u80ce
D5 & D6\u7684\u56ca\u80da<\/p>\n

\n

\u00a0<\/p>\n

\n

Human Reproduction\u00a0 2013\u5e741<\/span><\/span>\u670824<\/span><\/span>\u65e5<\/span><\/span>\u3002\u6436\u9bae\u7248\u00a0<\/span><\/span><\/p>\n<\/div>\n

\u00a0<\/span>\u51fa\u8655:<\/span>\u7b2c\u4e8c\u540d\u7684\u4e0d\u5b55\u75c7\u671f\u520a<\/span><\/p>\n

\n

\u00a0<\/p>\n

\u00a0<\/p>\n<\/div>\n

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<\/span>\u7814\u7a76\u7684\u554f\u984c\uff1a\u5375\u88c2\u671f(D3)<\/span>\u80da\u80ce\u79fb\u690d\u8207\uff08ET<\/span>\uff095\/6<\/span>\u5929\u7684\u56ca\u80da\u968e\u6bb5\u6240\u53d6\u5f97\u7684\u6210\u679c\u6bd4\u8f03\u55ae\u80ce\u598a\u5a20\u80ce\u5152\u7684\u751f\u7522\u5f71\u97ff><\/p>\n

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<\/span>\u9650\u5236\uff0c\u9700\u8981\u6ce8\u610f\u7684\u539f\u56e0\uff1a\u7522\u5f8c\u96a8\u8a2a\u7814\u7a76\uff0c\u4ee5\u78ba\u5b9a\u5982\u679c\u6211\u5011\u89c0\u5bdf\u5230\u9019\u7a2e\u5dee\u7570\u8f49\u5316\u70ba\u9577\u671f\u7684\u4e0d\u5229\u5f71\u97ff\uff0c\u9019\u4e9b\u5f8c\u4ee3\u3002\u65e9\u671f\u7684\u65e9\u7522\u7387\uff08<32<\/span>\u9031\uff09\u57285\/6<\/span>\u65e5\u8207\u7b2c3<\/span>\u5929\u9ad8\uff0c\u4f46\u6578\u91cf\u5f88\u5c11\u7684\u60c5\u6cc1\u4e0b\uff0c\u5728\u9019\u4e00\u985e\u6c92\u6709\u986f\u793a\u51fa\u5dee\u7570\uff083.0<\/span>\u5c0d2.7<\/span>\uff05\uff0cP = 0.34<\/span>\uff09\u3002<\/p>\n

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\u00a0<\/p>\n

\u9673<\/span><\/strong>\u91ab\u5e2b\u7684Comment:<\/span><\/span><\/strong><\/p>\n

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\u00a0<\/p>\n

Hum Reprod.<\/span><\/span><\/a>\u00a02013 Jan 24. [Epub ahead of print]<\/span><\/span><\/p>\n

Increased risk of preterm birth in singleton pregnancies after blastocyst versus Day 3 embryo transfer: Canadian ART Register (CARTR) analysis.<\/span><\/span><\/strong><\/p>\n

Dar S<\/span><\/span><\/a>,\u00a0<\/span>Librach CL<\/span><\/span><\/a>,\u00a0<\/span>Gunby J<\/span><\/span><\/a>,\u00a0<\/span>Bissonnette F<\/span><\/span><\/a>,\u00a0<\/span>Cowan L<\/span><\/span><\/a>;\u00a0<\/span>on behalf of the IVF Directors Group of the Canadian Fertility and Andrology Society<\/span><\/span><\/a>.<\/span><\/span><\/p>\n

Source<\/span><\/span><\/strong><\/p>\n

CReATe Fertility Center , 790 Bay Street, Suite 1100 , Toronto , Ontario , Canada M 5G 1N8 .<\/span><\/span><\/p>\n

Abstract<\/span><\/span><\/strong><\/p>\n

STUDY QUESTION:<\/span><\/span><\/strong><\/p>\n

Are the fetal outcomes of singleton pregnancies that result from cleavage stage embryo transfer (ET) different from the outcomes from Day 5\/6 blastocyst stage ET?<\/span><\/span><\/p>\n

SUMMARY ANSWER:<\/span><\/span><\/strong><\/p>\n

There was a significantly higher risk of preterm birth (<37 weeks) in singletons after extended embryo culture (Day 5\/6) compared with cleavage stage (Day 3) transfer.<\/span><\/span><\/p>\n

WHAT IS KNOWN ALREADY:<\/span><\/span><\/strong><\/p>\n

Two recent studies, from Sweden and the USA , reported an increased risk of preterm birth in singleton pregnancies after Day 5\/6 ET compared with Day 3 ET. The US study also showed increased early preterm births and the Swedish study showed increased fetal malformations in this group.<\/span><\/span><\/p>\n

STUDY DESIGN, SIZE AND DURATION:<\/span><\/span><\/strong><\/p>\n

A retrospective cohort study was performed. Data were collected from the Canadian ART Register database for all singleton births after fresh IVF\/ICSI ET cycles (2001-2009).<\/span><\/span><\/p>\n

PARTICIPANTS\/MATERIALS, SETTING, METHODS:<\/span><\/span><\/strong><\/p>\n

A total of 12 712 singleton births were included. Of these, 9506 resulted from a Day 3 ET and 3206 resulted from a blastocyst (Day 5\/6) ET.<\/span><\/span><\/p>\n

MAIN RESULTS AND THE ROLE OF CHANCE:<\/span><\/span><\/strong><\/p>\n

Preterm birth rate <37 weeks (unadjusted by potential confounding factors) was higher with Day 5\/6 versus Day 3 transfers (17.2 versus 14.1%, P < 0.001). Using logistic regression analysis to adjust for confounding factors, preterm birth rate <37 weeks was the only outcome significantly increased after Day 5\/6 compared with Day 3 transfer (odds ratio 1.32, 95% confidence interval 1.17-1.49). The following confounding factors were adjusted for: year of treatment (2001-2009), maternal age (continuous), parity (0 versus \u22651 birth), diagnosis category, number of oocytes retrieved [\u226420 versus >20 (high responder group)], insemination method (IVF versus ICSI), number of embryos transferred (1, 2 or \u22653) and the presence of a vanishing twin (\u22651 fetal heart on the initial ultrasonographic examination).<\/span><\/span><\/p>\n

LIMITATIONS, REASONS FOR CAUTION:<\/span><\/span><\/strong><\/p>\n

Post-natal follow-up studies will be required to determine if this difference we observed translates into adverse long-term effects on these offspring. The rate of early preterm births (<32 weeks) was higher in Day 5\/6 versus Day 3, but the low number of cases in this category did not have the power to show a difference (3.0 versus 2.7%, P = 0.34).<\/span><\/span><\/p>\n

WIDER IMPLICATIONS OF THE FINDINGS:<\/span><\/span><\/strong><\/p>\n

We found a significantly higher risk of preterm birth (<37 weeks) in singletons after extended embryo culture (Day 5\/6) compared with cleavage stage (Day 3) transfer, even when adjusting for confounding factors. Our findings are in agreement with the previous two studies; however, we did not show a difference in the very preterm deliveries (unlike the US study) or in fetal malformations (as in the Swedish study). We hypothesize that there may be a deleterious effect of prolonged in vitro embryo culture on subsequent placentation. Longer term follow-up studies will be required to determine if prolonged in vitro culture to the blastocyst stage has an adverse effect on the long-term health of offspring when compared with shorter cleavage stage culture.<\/span><\/span><\/p>\n

\u00a0<\/p>\n","protected":false},"excerpt":{"rendered":"

\u00a0D3 \u7684\u80da\u80ceD5 & D6\u7684\u56ca\u80da \u00a0 Human Reproduction\u00a0 2013\u5e741\u670824\u65e5\u3002 […]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[2],"tags":[],"class_list":["post-1230","post","type-post","status-publish","format-standard","hentry","category-know-how"],"_links":{"self":[{"href":"https:\/\/www.becphd.pro\/index.php?rest_route=\/wp\/v2\/posts\/1230","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.becphd.pro\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.becphd.pro\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.becphd.pro\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.becphd.pro\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=1230"}],"version-history":[{"count":0,"href":"https:\/\/www.becphd.pro\/index.php?rest_route=\/wp\/v2\/posts\/1230\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.becphd.pro\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=1230"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.becphd.pro\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=1230"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.becphd.pro\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=1230"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}