{"id":1459,"date":"2018-12-27T10:30:22","date_gmt":"2018-12-27T02:30:22","guid":{"rendered":"http:\/\/becphd.pro\/?p=1459"},"modified":"2018-12-27T10:30:22","modified_gmt":"2018-12-27T02:30:22","slug":"%e7%84%a1%e7%b4%b0%e8%83%9edna%e6%b8%ac%e8%a9%a6%e5%b8%82%e5%a0%b4%e9%a0%90%e6%b8%ac%e7%b2%be%e9%86%ab%e5%ad%b8%e7%9a%84%e5%a4%a7%e8%b6%a8%e5%8b%a2","status":"publish","type":"post","link":"https:\/\/www.becphd.pro\/?p=1459","title":{"rendered":"\u7121\u7d30\u80deDNA\u6e2c\u8a66\u5e02\u5834\u9810\u6e2c\u7cbe\u6e96\u91ab\u5b78\u7684\u5927\u8da8\u52e2"},"content":{"rendered":"<p><strong>\u7121\u7d30\u80deDNA\u662fDNA\u7684\u7247\u6bb5\uff0c\u5176\u5728\u8840\u6db2\u4e2d\u5faa\u74b0\u4e26\u4e14\u53ef\u4ee5\u7528\u4f5c\u6709\u50f9\u503c\u7684\u751f\u7269\u6a19\u8a8c\u7269\u3002\u9019\u662f\u4e00\u7a2e\u65b0\u6280\u8853\uff0c\u5176\u4e2d\u6536\u96c6\u4f86\u81ea\u60a3\u8005\u7684\u5c11\u91cf\u6db2\u9ad4\u6a23\u54c1\uff08\u553e\u6db2\uff0c\u5c3f\u6db2\u6216\u8840\u6db2\uff09\u4ee5\u6aa2\u67e5\u81ea\u7531\u6d41\u52d5\u7684DNA\u3002\u7121\u7d30\u80deDNA\uff08cfDNA\uff09\u662f\u4e00\u7a2e\u975e\u4fb5\u5165\u6027\u7be9\u9078\u8a66\u9a57\uff0c\u7528\u65bc\u5e6b\u52a9\u6aa2\u6e2c\u79fb\u690d\u7269\u6392\u65a5\uff0c\u8b58\u5225\u764c\u75c7\u60a3\u8005\u7684\u7a81\u8b8a\u4e26\u6aa2\u6e2c\u80ce\u5152\u4e2d\u7684\u5404\u7a2e\u67d3\u8272\u9ad4\u7570\u5e38\uff0c\u4ee5\u4e86\u89e3\u80ce\u5152\u7684\u6027\u5225\u3002 cfDNA\u7684\u767c\u73fe\u958b\u95e2\u4e86\u816b\u7624\u5b78\uff0c\u5a66\u79d1\u5b78\uff0c\u79fb\u690d\u548c\u50b3\u67d3\u75c5\u9818\u57df\u7684\u65b0\u6f5b\u529b\u3002<\/strong><\/p>\n<p><strong>\u7121\u7d30\u80deDNA\u6e2c\u8a66\u5e02\u5834\u6839\u64da\u5176\u61c9\u7528\uff0c\u985e\u578b\u548c\u5340\u57df\u9032\u884c\u7d30\u5206\u3002\u5728\u61c9\u7528\u7684\u57fa\u790e\u4e0a\uff0c\u5e02\u5834\u5206\u70ba\u816b\u7624\u5b78\uff0c\u5a66\u79d1\u5b78\u548c\u79fb\u690d\u5b78\u3002\u6309\u985e\u578b\uff0c\u5e02\u5834\u9032\u4e00\u6b65\u7d30\u5206\u70ba\u6350\u8d08\u8005\u884d\u751f\u7684\u7121\u7d30\u80de\u7684DNA\uff08ddcfDNA\uff09\uff0c\u816b\u7624\u5728\u8840\u6db2\u5faa\u74b0\u7121\u7d30\u80de\u7684DNA\uff08ctDNA\uff09\u548c\u7121\u7d30\u80de\u80ce\u5152\u6e38\u96e2\u65bc\u6bcd\u8840\u7684DNA\uff08NIPT\uff09\u3002(donor derived cell free DNA (ddcfDNA), circulating cell-free tumor DNA (ctDNA) and cell-free fetal DNA (NIPT). 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Technology\uff0cAllenex AB\uff0cBiocept\uff0cInc.\uff0cBiodesix\uff0cInc.\uff0cCareDx\uff0cInc\u3002Guardant Health\uff0cInc.\uff0cIllumania\uff0cInc.\uff0cInivated Limited\uff0cNatera\uff0cInc \u3002\uff0cQuest Diagnostics\uff0cRoche Holdings AG\uff0c<\/strong><strong>\u200b\u200b<\/strong><strong>Sequenom<\/strong><strong>\uff0cInc\u3002\u548cTrovagene\uff0cInc\u3002\u5168\u7403\u7121\u7d30\u80deDNA\u6aa2\u6e2c\u5e02\u5834\u662f\u4e00\u500b\u7af6\u722d\u6fc0\u70c8\u7684\u5e02\u5834\uff0c\u6240\u6709\u53c3\u8207\u8005\u90fd\u53c3\u8207\u901a\u904e\u5408\u4f75\u548c\u6536\u8cfc\u958b\u767c\u65b0\u7684\u6aa2\u6e2c\u65b9\u6cd5\u3002\u5e02\u5834\u4e26\u4fdd\u6301\u5176\u5e02\u5834\u4efd\u984d\u3002\u4f8b\u5982\uff0c\u7f85\u6c0f\u63a7\u80a1\u516c\u53f8\uff08Roche Holdings AG\uff09\u7372\u5f97\u7f8e\u570bFDA\u6279\u51c6\u5176\u65b0\u63a8\u51fa\u7684ctDNA\u6e2c\u8a66Cobas\uff0c\u8a72\u6e2c\u8a66\u88ab\u6279\u51c6\u7528\u65bc\u57fa\u65bc\u8840\u6db2\u7684\u57fa\u56e0\u6e2c\u8a66\u3002\u7f85\u6c0f\u9084\u901a\u904e\u6536\u8cfcAriosa\u8a3a\u65b7\u9032\u5165NIPT\u5e02\u5834\u3002 CareDx\uff0cInc\u3002\u6536\u8cfc\u4e86Allenex AB\uff0c\u56e0\u5176\u5728\u814e\u81df\u548c\u5fc3\u81df\u79fb\u690d\u60a3\u8005\u7684\u4f9b\u9ad4\u884d\u751f\u7684\u7121\u7d30\u80deDNA\u6aa2\u6e2c\u65b9\u9762\u7684\u65b0\u767c\u5c55\u3002<\/strong><\/p>\n<p><strong>\u00a0<\/strong><\/p>\n<p><strong>\u76ee\u524d\u56e0\u70ba\u5728\u61f7\u5b55\u671f\u9593\uff0c\u6bcd\u89aa\u53ef\u4ee5\u900f\u904e\u80ce\u76e4\u4ea4\u63db\u6c27\u6c23\u548c\u990a\u5206\u4f9b\u7d66\u80ce\u5152\u6210\u9577\u6240\u9700\uff0c\u6b64\u6642\u5c31\u6703\u6709\u4e00\u4e9b\u80ce\u5152\u7684DNA\u7247\u6bb5\u6e38\u96e2\u5230\u6bcd\u89aa\u7684\u8840\u6db2\u4e2d\uff0c\u56e0\u6b64\u5728\u61f7\u5b5510\u5468\u4ee5\u4e0a\uff0c\u5f9e\u5b55\u5a66\u7684\u8840\u6f3f\u4e2d\uff0c\u5c31\u53ef\u4ee5\u5075\u6e2c\u52305%~10%\u7684\u80ce\u5152\u6e38\u96e2DNA\uff0c\u9019\u4e9bDNA\u7d93\u7531\u6b21\u4e16\u4ee3\u9ad8\u901a\u91cf\u5b9a\u5e8f\u5f8c\uff0c\u53ef\u4ee5\u5f97\u5230\u6578\u5343\u842c\u689d\u7684DNA\u5e8f\u5217\u8cc7\u8a0a\uff0c\u5206\u6790\u5f8c\u5c31\u53ef\u5224\u65b7\u6bcf\u500bDNA\u7247\u6bb5\u7684\u4f86\u6e90\u67d3\u8272\u9ad4\uff0c\u53ea\u8981\u6709\u767c\u73fe\u7279\u5b9a\u67d3\u8272\u9ad4\u7684DNA\u7247\u6bb5\u7570\u5e38\u589e\u52a0\uff0c\u80ce\u5152\u5c31\u53ef\u80fd\u6709\u8a72\u67d3\u8272\u9ad4\u5957\u6578\u7570\u5e38\u7684\u554f\u984c\u3002\u76ee\u524dNIPT\u53ef\u4ee5\u6e96\u78ba\u7684\u7be9\u6aa2\u51fa\u5510\u6c0f\u75c7(Down syndrome, trisomy 21)\u3001\u611b\u5fb7\u83ef\u6c0f\u75c7(Edward syndorme, trisomy 18)\u3001\u5df4\u9676\u6c0f\u75c7(Patau syndrome, trisomy 13)\u3001\u900f\u7d0d\u6c0f\u75c7(Turner syndrome, monosomy X)\u548c\u514b\u6c0f\u75c7\u5019\u7fa4(Klinefelter syndrome, XXY)\u7b49\uff0c\u5510\u6c0f\u75c7\u548c\u611b\u5fb7\u83ef\u6c0f\u75c7\u7684\u6aa2\u51fa\u7387\u9ad8\u905499%\u4ee5\u4e0a\uff0c\u70ba\u76f8\u7576\u6e96\u78ba\u7684\u67d3\u8272\u9ad4\u6578\u76ee\u7570\u5e38\u7684\u7be9\u6aa2\u65b9\u6cd5\uff0c\u53ef\u53d6\u4ee3\u76ee\u524d\u7684\u7b2c\u4e00\u5b55\u671f\u5510\u6c0f\u75c7\u7be9\u6aa2(\u6e96\u78ba\u7387\u7d0485%)\u53ca\u7b2c\u4e8c\u5b55\u671f\u5510\u6c0f\u75c7\u7be9\u6aa2(\u6e96\u78ba\u7387\u7d0483%)\u3002<\/strong><\/p>\n<p><strong>\u4e00\u4e9b\u5927\u7247\u6bb5\u7684\u55ae\u57fa\u56e0\u75be\u75c5(3MB)\u4e5f\u80fd\u5075\u6e2c\u5230\u6578\u5341\u9805\u55ae\u57fa\u56e0\u75be\u75c5\u3002<\/strong><\/p>\n<p><strong>\u00a0<\/strong><\/p>\n<p><strong>NIPT<\/strong><strong>\u7684\u512a\u9ede:<br \/>\n\u63a1\u6a23\u7c21\u4fbf\u53ca\u5b89\u5168\uff0c\u61f7\u5b5510\u5468\u4ee5\u4e0a\u7684\u5b55\u5a66\u76f4\u63a5\u62bd\u8840\uff0c\u5c31\u53ef\u4ee5\u5075\u6e2c\u80ce\u5152\u662f\u5426\u6709\u67d3\u8272\u9ad4\u6578\u76ee\u7570\u5e38(fetal aneuploidy)\u7684\u72c0\u6cc1\uff0c\u907f\u514d\u7f8a\u819c\u7a7f\u523a\u5343\u5206\u4e4b\u4e00\u7684\u6d41\u7522\u98a8\u96aa\u3002<\/strong><\/p>\n<p><strong>\u25ce<\/strong><strong>\u00a0NIPT<\/strong><strong>\u7684\u9650\u5236:<br \/>\n\u53ea\u80fd\u5075\u6e2c\u67d3\u8272\u9ad4\u5957\u6578\u7570\u5e38\uff0c\u7121\u6cd5\u5075\u6e2c\u67d3\u8272\u9ad4\u7d50\u69cb\u7684\u7570\u5e38\uff0c\u56e0\u6b64\u4ecd\u7121\u6cd5\u53d6\u4ee3\u7f8a\u819c\u7a7f\u523a\u67d3\u8272\u9ad4\u6aa2\u67e5\u3002<\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u7121\u7d30\u80deDNA\u662fDNA\u7684\u7247\u6bb5\uff0c\u5176\u5728\u8840\u6db2\u4e2d\u5faa\u74b0\u4e26\u4e14\u53ef\u4ee5\u7528\u4f5c\u6709\u50f9\u503c\u7684\u751f\u7269\u6a19\u8a8c\u7269\u3002\u9019\u662f\u4e00\u7a2e\u65b0\u6280\u8853\uff0c\u5176\u4e2d\u6536\u96c6\u4f86\u81ea\u60a3\u8005\u7684\u5c11 [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[2,8],"tags":[],"class_list":["post-1459","post","type-post","status-publish","format-standard","hentry","category-know-how","category-news"],"_links":{"self":[{"href":"https:\/\/www.becphd.pro\/index.php?rest_route=\/wp\/v2\/posts\/1459","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.becphd.pro\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.becphd.pro\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.becphd.pro\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.becphd.pro\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=1459"}],"version-history":[{"count":0,"href":"https:\/\/www.becphd.pro\/index.php?rest_route=\/wp\/v2\/posts\/1459\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.becphd.pro\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=1459"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.becphd.pro\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=1459"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.becphd.pro\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=1459"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}