冷凍胚胎植入與新鮮週期胚胎植入相比顯著降低子宮外孕的的發生率

2018 年 7 月 19 日陳啟煌

生育與絕育搶鮮版 2012年8月24日來自美國的研究。

不孕症第三名的期刊

冷凍胚胎植入與新鮮週期胚胎植入相比顯

著降低子宮外孕的的發生率。

內華達大學醫學院婦產科系，內華達州的拉斯維加斯，內華達

州的拉斯維加斯，。

目的：
比較冷凍胚胎植入與新鮮週期胚胎植入後子宮外孕(EP）的發病率。

設計：
回顧性隊列研究。

單位：
私人生育中心。

病人（S）：
這項回顧性研究在8年的研究期間2004-2011包括2,150的囊胚植入，包括1,460新鮮囊胚植入和690 (day 1 2PN)冷凍胚胎解凍後培養至囊胚植入。

介入治療（S）：
無。

主要觀察指標（S）：
可視化的EP和處理持久性不明位置妊娠。

結果（S）：
子宮外孕在懷孕的新鮮囊胚植入為1.5％，(day 1 2PN)冷凍胚胎解凍後培養至囊胚植入子宮外孕為0。在這兩個群體治療的持續性不明位置妊娠率分別為2.5％和0.3％，分別為，此差異也有統計學意義（相對危險度為7.3，95％可信區間為1.7-31.0）。

結論（S）：
冷凍胚胎解凍後培養至囊胚植入與新鮮週期新鮮囊胚植入相比顯著降低子宮外孕的的發生率。

Fertil Steril. 2012 Aug 24. [Epub ahead of print]

Frozen-thawed embryo transfer is associated with a significantly reduced incidence of ectopic pregnancy.

Shapiro BS, Daneshmand ST, De Leon L, Garner FC, Aguirre M, Hudson C.

Source

Fertility Center of Las Vegas, Las Vegas, Nevada; Department of Obstetrics and Gynecology, University of Nevada School of Medicine, Las Vegas, Nevada.

Abstract

OBJECTIVE:

To compare the incidence of ectopic pregnancy (EP) after fresh ET and thawed ET.

DESIGN:

Retrospective cohort study.

SETTING:

Private fertility center.

PATIENT(S):

This retrospective study included 2,150 blastocyst transfers, including all 1,460 fresh autologous blastocyst transfers and all 690 transfers of autologous blastocysts derived from post-thaw extended culture of thawed bipronuclear oocytes in the 8-year study period 2004-2011.

INTERVENTION(S):

None.

MAIN OUTCOME MEASURE(S):

Visualized EP and treated persistent pregnancy of unknown location.

RESULT(S):

The rate of visualized EP was 1.5% in pregnancies in fresh autologous cycles, which was significantly more than the rate of 0 with autologous post-thaw extended culture. The rates of treated persistent pregnancy of unknown location were 2.5% and 0.3% in these two groups, respectively, a difference that was also statistically significant (relative risk 7.3, 95% confidence interval 1.7-31.0).

CONCLUSION(S):

Relative to fresh transfer, thawed ET was associated with significantly reduced incidence of EP. These findings are consistent with ovarian stimulation increasing the risk of EP.