非常恭喜詹欣雨醫師!
畢業自UCLA生物系,陽明醫學系,北醫附醫住院醫師,總醫師,本月完成艱苦的人工生殖施術醫師專科訓練的最後一塊拼圖(SCI論文發表)於十月一日在著名的
“Journal of Assisted Reproduction and Genetics”由陳啟煌醫師指導”研究男性卡門綜合症基因突變的跨世代變化”,經5位外籍評審長達半年嚴審多數決接受刊登。
詹醫師非常nice,謙虛,也是台北醫學大學附設醫院婦產部教學長,可見知識與耐心,本月同時躍升台北醫學大學附設醫院生殖醫學中心專任主治醫師。再度狂賀!
分類: 今日北醫
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醫師介紹-2
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醫師介紹-1
非常恭喜🎉🎊🍾️🎈
三軍總醫院婦產部劉勇良博士助理教授歷經台北醫學大學附設醫院生殖醫學中心兩年四千多例試管嬰兒的紮實訓練完訓，由我發出任內第二張人工生殖施術醫師訓練資格証明，如同研究所畢業榮獲畢業証書，我兩都笑的開心，非常非常祝賀大家公認優秀又nice的劉勇良醫師回到國防醫學院及三軍總醫院大展身手，鵬程萬里，病人多多，成功率高高！開心😃
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胚胎縮時攝影監控培養箱(Time Lapse System + Embryoscope)
孩子成長的點點滴滴 從胚胎開始-
胚胎縮時攝影監控培養箱(Time Lapse System + Embryoscope)從受精當天-試管嬰兒療程day 0到day 6的發展過程可以動態觀察,實驗室人員及求孕者可以觀察到如同電影快轉般參與胚胎的縮影幾十秒到幾分鐘,不用徬徨的問胚胎好壞或醫師無法滿足解釋胚胎後您的疑慮,乃至上網查google大神或問非醫療人員的試管戰友。
台北醫學大學附設醫院生殖之學中心，引進全世界最頂尖第一品牌的胚胎縮時攝影監控培養箱 “Embryoscope Plus” by Vitrolife . Embryoscope plus近千萬醫療儀器更進一步提升試管療程的醫療品質，猶如超跑一般讓人驚艷。
Embryoscope+培養箱模擬母體子宮內的環境並且每10分鐘為胚胎拍照一次捕捉胚胎從受精後到第5至6天的一舉一動達到不間斷培養，不只可以提供胚胎一個穩定不被打擾的培養環境同時間又可以大量獲取胚胎資訊。
一般傳統培養法為了不打擾胚胎發育情形下，觀測的時間點往往受限住，只能每天特定時段將胚胎拿出培養箱外觀察記錄，並利用囊胚的等級(David Gardner’s System)去預測此囊胚的著床率，但忽略了胚胎在培養過程中所有重要的資訊。現在開始我們即將不一樣了，小孩的回憶不該只是從出生算起，而是從受精當下開始陪伴成長，我們將提供胚胎唯一發育過程影片讓為人父母的您分享懷孕喜悅。
利用胚胎縮時攝影監控培養箱 Embryoscope+ 可擷取到胚胎在發育中所釋放出任何重要的訊息，例如:
1. 胚胎是否在正確的時間點進行分裂(Cleavage timing)
2. 胚胎分裂是否有異常: (Cleavage Regularity)
A. 直接分裂(Direct Unequal Cleavage): 細胞分裂 1-3, 2-5
B. 融和分裂(Reverse Cleavage): 細胞分裂後又融合回去
C. 多核細胞(Multinucleation): 多個細胞核存在於一顆細胞內
3. 細胞分裂步驟的時間差 (Developmental Speed)
4. 囊胚品質 (Blastocyte Quality)
上述所提到的幾個觀點的重要性都在多篇科學文章中被一一論證Embryoscope+ 所搭配的軟體KIDscore (Known Implantation Data)是收集了全球超過500萬張成功著床的胚胎生長曲線圖去創造了一個大數據資料庫，同時運用AI人工智慧標準化系統評估胚胎分裂時間點。
KIDscore不僅僅是一個資料庫，同時還能對胚胎進行評分，進而選出品質最優的胚胎來植入，對於療程不順遂以及求子心切的不孕症夫婦大大提升植入率以及著床率。https://www.facebook.com/DrBabyChen/videos/1409559542543383/
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陳啟煌醫師覺得感恩──在台北醫學大學附設醫院。
感謝2011年3月1日進入台北醫學大學附設醫院最具國內外知名度且與國際接軌的生殖醫學中心任主治醫師。在優良專業的特色醫療單位工作，戰戰兢兢，不敢鬆懈，伴隨著病人的喜怒哀樂，來自海內外病患的擁載期望完成很多人的夢想。也在忙裏偷閒讀完博士畢業，順利升等到副教授。也不忘為台灣及北醫爭光，榮獲國際多次學術大獎，也深受対岸經常性的應邀專業演講。懷孕率與人次與日激增。蒙此重責大任今日接獲人事命令：自2019.08.09接掌生殖醫學中心主任，隸屬於生殖醫學科管轄。同時身為生殖醫學科主任的我只有不斷擦亮新技術與知識，好好敎導一干進修醫師。在這0與100的試管療程，追求完美，近乎苛求。
謝謝大家對我的支持。🙏🙏🙏
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【國際成功案例】-香港
台灣的試管嬰兒懷孕率，亞洲第一名 ，台北醫學大學生殖中心 遠近馳名，收費合理，近年來不論是港澳人士、或是大陸內地朋友絡繹而來，對我們國際醫療水平的肯定與支持，讓我們真的很自豪，這對從香港來台的夫妻更是親自見證體驗了這醫療服務。
31歲在香港他們是「求孕」很緊張的年紀，認爲30歲結婚了，如果還沒懷孕，就會受到很多親戚朋友的關心詢問。反觀台灣的少子化問題日趨嚴重，35歲結婚都還沒有急着求孕，這已經是目前的國安危機了。
這對夫妻寧願選擇搭機前來就診，對我們北醫的生殖團隊，除了肯定只有肯定，我們也不負眾望 ,讓他們充滿喜悅的期待新成員加入。
北醫門診掛號➡https://bit.ly/2SIPosI
君蔚生殖中心掛號➡https://bit.ly/2LfH40v
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醫學學術著作集
學術著作
First and Correspondence
1. Chen CH, Chen SG, Wu GJ, Wang J, Yu CP, Liu JY. Autologous heterotopic transplantation of intact rabbit ovary after
cryopreservation at -196℃. Fertil Steril 2006 Oct; 86 (3):1059-66. Impact factor: 4.803
2. Chen CH, Chen IC, Wang YC, Liu JY, Wu GJ, Tzeng CR. Boy born after gender preselection following successive
gestational androgen excess of maternal luteoma and female disorders of sex development Fertil Steril 2009 Jun;
91(6):2732.e5-7. Epub 2008 Dec 24 Impact factor: 4.803
First author
3. Chen CH, Huang YH, Lai WF, Wang CW, Hsu MI, Tzeng CR. Bioluminescence imaging (BLI) as a tool to evaluate germ
cell in vitro and transplantation in vivo as fertility preservation of prepubertal male mice. Fertility Sterility 2012 May; 97
(1) : 192-8. Impact factor: 4.803
4. Chen CH, Zhang X, Confino E, Milad M, Kazer RR. Relationships between peak serum estradiol levels and treatment
outcome in in vitro fertilization cycles following embryo transfer on day 3 or day 5. Fertil Steril 2003; 80:75-9. Impact
factor: 4.803
5. Chen CH, Huang RL, Yu MS, Wong LJC, Chao TF, and Chu TY. Hereditary nonpolyposis colorectal cancer with
gynecologic malignancies: report two families in Taiwan. J Formos Med Assoc 2001; 100:269-73. Impact factor: 1.695
(38%)
6. Chen CH, Lee SS, Chen DC, Chien HH, Chen IC, Chu YN, Liu JY, Chen WH, Wu GJ. Apoptosis and kinematics of
ejaculated spermatozoa in patients with varicocele. J Androl. 2004 May-Jun; 25(3):348-53. Impact factor: 1.694 (57.1%)
7. Chen CH, Yeh YC, Wu GJ, Huang YH, Thomas Lai WF, Liu JY, Tzeng CR. Tracking the rejection and survival of mouse
ovarian iso- and allografts in vivo with bioluminescent imaging. Reproduction 2010; 140: 105-112. Impact factor: 3.262
(23.3%)
8. Chen CH, Tan SJ, Tzeng CR. In vivo fate mapping of cryopreserved murine ovarian grafts. J Ovarian Res. 2014 Aug;7:81-7.
Impact factor: 2.030 (56.7%)
9. Chen CH, Tzeng CR. Ovarian tissue transplantation: current state and research advancement. Curr Obstet Gynecol Rep.
2013 Dec;2(4):202-210. (Review article)
Correspondence
10. Tan SJ, Yeh YC, Shang WJ, Wu GJ, Liu JY, Chen CH. Protective effect of a gonadotropin-releasing hormone analogue on
chemotherapeutic agentinduced ovarian gonadotoxicity: A mouse model. Eur J Obstet Gynecol Reprod Biol 2010; 149:
182–185 Impact factor: 1.627 (57.7%)
11. Lin CK, Chang WH, Pan HH, Chen CH. Postpartum hellp syndrome with unusually high levels of liver enzymes. Taiwan J
Obstet Gynecol 2009 Sep; 48(3) Impact factor: 1.261 (73.1%)
12. Chen DC, Chen CH, Liu JY, Ku CH, Wu GJ. Serum vascular endothelial growth factor165 levels and uterine fibroid
volume. Acta Obstet Gynecol Scan 2005; 84(4):317-21. Impact factor: 1.985 (39.7%)
13. Su HY, Chen CH, Gao HW, Liu JY. A bicornuate uterus with a unilateral cornual adenomyosis. Obstet gynecol 2005 May;
105(5):1191-3. Impact factor: 4.368 (3.8%)
14. Wang YC, Su HY, Liu JY, Chang FW, Chen CH. Maternal and female fetal virilization caused by pregnancy luteomas.
Fertil Steril 2005 Aug;84(2):509 (SCI) Impact factor: 4.295 (5.1%)
15. Su HY, Liu HY, Chen CH. Pelvic inflammatory disease combined with perforated peptic ulcer -mimicking tubo-ovarian
abscess. Int J Gynaecol Obstet. 2005 Mar; 88(3):329-30. Impact factor: 1.563 (64.1%)
16. Su HY, Chen WH, Chen CH. Extra-pelvic endometriosis presenting as a vulvar mass in a teenage girl. Int J Gynaecol
Obstet. 2004 Dec; 87(3):252-3. Impact factor: 1.563 (64.1%)
17. Chang FW, Yu MH, Wu CC, Chen WH, Chen CH. Cornual pregnancy treated with dilatation and curettage under
laparoscopic guidance- a report of two cases. Taiwanese J Obstet Gynecol. 2004; 43(4):229-231. Impact factor: 1.261
(73.1%)
18. Wu CJ, Peng YJ, Yu MH, Chen CH*. Secretory adenocarcinoma of endometrium in a postmenopausal patient with breast
cancer using tamoxifen. Taiwanese J Obstet Gynecol 2007 Mar; 46( 1). Impact factor: 1.261 (73.1%)
19. Chang WH and Chen CH. Unilateral obstructive uropathy caused by deep infiltrating endometriosis. J Med Sci 2008;
28(2):99-102.
20. Chang WH, Lin CK, Chiang YJ, Chen CH. Puerperal hematoma combined with retroperitoneal dissection & obstructive
uropathy. J Med Sci 2008; 28(2): 81-84.
21. Chang WH, Liu JY, Yeh YC, Wu GJ, Chiang YJ, Yu MH, Chen CH*. Tubal ligation via colpotomy or laparoscopy: a
retrospective comparative study. Arch Gynecol Obstet. 2011; 283:805-808 Impact factor: 1.279 (71.8%)
22. Lin YH, Chang FW, Chen CH . Perimenopausal amenorrhea with cervical atresia and hematotrachelos. Journal of Medical
Sciences 2010 Aug; 30(4).
23. Lin YS, Yeh YC, Tzeng CR, Shang WJ, Wu GJ, Liu JY and Chen CH. Evaluating the effects of immunosuppression by in
vivo bioluminescence imaging after allo-transplantation of ovarian grafts. Reproductive Biomedical Online 2010;
22:220-227. Impact factor: 2.980 (15.4%), RBM online年度最佳論文第二名24. Tsai YC, Tzeng CR, Wang CW, Hsu MI, Tan SJ, Chen CH. Antiapoptotic agent sphingosine-1-phosphate protects vitrified
murine ovarian grafts. Reprod Sci. 2014 Feb;21(2):236-43. Impact factor 2.179 (33.3%)
25. Tan SJ, Lee LJ, Tzeng CR, Wang CW, Hsu MI, Chen CH. Targeted anti-apoptosis activity for ovarian protection against
chemotherapy-induced ovarian gonadotoxicity.Reprod Biomed Online. 2014 Nov;29(5):612-20. Impact factor: 2.980
(15.4%)
Co-author
26. Zhang X, Chen CH, Confino E, Barnes R, Milad M, Kazer RR. Increasing endometrial thickness is associated with
improved treatment outcome for selected patients undergoing in vitro fertilization-embryo transfer. Fertil Steril 2005;
83:336-40. Impact factor: 4.803
27. Wang YC, Chen CH, Su HY, Li HS, Liu Y. Huge spindle cell hemangioma of the cervix-mimicking a pelvic tumor.
Gynecol Obstet Invest 2005 April 27; 60(2):98-101. Impact factor: 1.251 (74.4%)
28. 26. Wang YC, Liu JJ, Chen CH, Peng YJ, Yu MH. Peritoneal tuberculosis mimicking ovarian cancer can be diagnosed by
polymerase chain reaction: a case report. Gynecol Oncol 2005 Jun; 97(3):961-963 Impact factor: 3.687 (9.0%)
29. Chen DC, Chen CH, Su HY, Yu CP, Chen WH, Yu MH. Retroperitoneal lymphangiomyomas presenting as a pelvic mass.
Acta Obstet Gynecol Scand 2005 Sep; 84(9):917-20. Impact factor: 1.985 (39.7%)
30. Chang WH, Chen CH, Yu MS. Conservative therapy of stage I endometrial adenocarcinoma and atypical endometrial
hyperplasia for the preservation of fertility. Int J Gynaecol Obstet. 2006; 92(2):137-8 Impact factor: 1.563 (64.1%)
31. Wang YC, Chen CH, Su HY, Yu MH. The impact of maternal cardioversion on fetal haemodynamics European Journal of
Obstetrics & Gynecology and Reproductive Biology 2006 Jun 1; 126(2):268-274. Impact factor: 1.627 (57.7%)
32. Chen DC, Ku CH, Huang YC, Chen CH, Wu GJ. Urinary nitric oxide metabolite changes in spontaneous and induced onset
active labor. Acta Obstet Gynecol Scand. 2004 Jul; 83(7):641-6. Impact factor: 1.985 (39.7%)
33. Chen DC, Chen CH, Su HY, Yu CP, Chen WH, Chu TY. Huge pedunculated fibroma of the vulva. Acta Obstet Gynecol
Scand 2004; 83:1091-2. Impact factor: 1.985 (39.7%)
34. Chang FW, Chen CH, Liu JY. Early diagnosis of ovarian pregnancy by ultrasound. Int J Gynaecol Obstet. 2004 May;
85(2):186-187. Impact factor: 1.563 (64.1%)
35. Huang HC, Chen CH, Chu CC, Yu CP, Chu TY. Mature cystic teratoma of ovary with gliomatosis peritonei. J Med Sci
2004; 24(6):343-346.
36. Chang FW, Yu MH, Ku CH, Chen CH, Wu GJ, Liu JY. Effect of uterotonics on intra-operative blood loss during
laparoscopy-assisted vaginal hysterectomy: a randomised controlled trial. BJOG 2006 Jan; 113(1):47-52. Impact factor:
3.862 (7.7%)
37. Ding DC, Huang RL, Chen CH, Chao CF, Chu TY. Novel germline and somatic mutations of the MSH2 gene in hereditary
non-polyposis colorectal cancer. Clin Genet 2007; 71: 190–192. Impact factor: 3.652 (29.9%)
38. Wu GJ, Chang FW, Lee SS, Cheng YY, Chen CH, Chen IC. Apoptosis-related phenotype of ejaculated spermatozoa in
patients with varicocele. Fertility Sterility 2009 Mar; 91(3):831-837. Impact factor: 4.295 (5.1%)
39. Liu YL, Chen CH, Liu JY, Chang FW, Chen IC, Chien HH, Wu GJ. Influence of late follicular luteinizing hormone
concentrations on ovarian response and fertilization outcome in patients undergoing in vitro fertilization with a short
protocol. J Med Sci 2009; 29(4):195-198.
40. Chen HC, Sytwu JK, Chang JL, Wang HW, Chen HK, Kang BH, Liu DW, Chen CH, Chao TT, Wang CH. Hypoxia
enhances the stemness markers of cochlear stem/progenitor cells and expands sphere formation through activation of
hypoxia-inducible factor-1 alpha. Hearing Research 2010; 275:43-52. Impact factor: 2.848 (9.1%)
41. Chen HS, Ma HI, Sytwu HK, Wang HW, Chen CCV, Liu SC, Chen CH, Chen HK and Wang CH. Neural stem cells secrete
factors thatpromote auditory cell proliferation via a leukemia inhibitory factor signaling pathway. J Neurosci Res. 2010 Nov
15; 88(15):3308-3318. Impact Factor: 2.986 (45.2%). Impact factor 2.729 (56.2%)
42. Liang SJ, Hsu CS, Tzeng CR, Chen CH, Hsu MI. Clinical and biochemical presentation of polycystic ovary syndrome in
women between the ages of 20 and 40. Hum Reprod. 2011 Dec ;26(12):3443-3449. Impact factor 4.585(2.6%)
43. Lin HC, Chen CH, Su HY. Bier’s Spots on Legs Associated with Deep Vein Thrombosis during Pregnancy. Taiwan J Obstet Gynecol. 2015 Feb;54(1):102-4 Impact factor: 1.261 (73.1%)
44. Wu HM, Tzeng CR, Chen CH, Chen PH. Pelvic endometriosis with peritoneal fluid reduces pregnancy rates in women
undergoing intrauterine insemination. Taiwan J Obstet Gynecol. 2013 Dec;52(4):512-515. Impact factor: 1.261 (73.1%)
45. Tzeng CR, Chang YC, Chang YC, Wang CW, Chen CH, Hsu MI. Cluster analysis of cardiovascular and metabolic risk
factors in women of reproductive age. Fertil Steril. 2014 May;101(5): 1404-1410. Impact factor: 4.295 (5.1%)
46. Wang MH, Chen CH, Wang CW, Hsu MI, Tzeng CR. A higher anti-Müllerian hormone level is associated with an
increased chance of pregnancy in patients undergoing controlled ovarian stimulation and intrauterine insemination. J Obstet Gynaecol. 2015 Jan;35(1):64-8. Impact factor: 0.604 (92.3%)47. Lin HC, Chen CH, Su HY. Bier spots on legs associated with deep vein thrombosis during pregnancy. Taiwan J Obstet Gynecol. 2015 Feb;54(1):102-4.
48. Hsu MI, Wang CW, Chen CH, Tzeng CR. Impact of the number of retrieved oocytes on pregnancy outcome in in vitro fertilization. Taiwan J Obstet Gynecol. 2016 Dec;55(6):821-825.
49. Wang CY, Lai YJ, Hwang KS, Chen CH, Yu MH, Chen HT, Su HY. Successful treatment with granulocyte-colony stimulating factor for ritodrine-induced neutropenia in a twin pregnancy. Taiwan J Obstet Gynecol. 2016 Oct;55(5):738-740.
50. Chang-Chih Hsieh, Chi-Huang Chen*, Szu-Yu Shen, Chii-Ruey Tzeng. Babies born from three young infertile sisters with premature ovarian insufficiency caused by inherited Fragile X syndrome: an intergenerational report. Taiwan J Obstet Gynecol. 2017 Feb;56(1):112-113 (corresponding author)
51. Chen CW, Huang YL, Tzeng CR, Huang RL and *Chen CH (責任作者) Idiopathic Low Ovarian Reserve Is Associated with More Frequent Positive Thyroid Peroxidase Antibodies. Thyroid 2017 Sep;27(9):1194-1200. Impact factor: 7.557.
52. Lee YX, Chen CW, CR Tzeng and *CH Chen (責任作者) Predicted a rare chromosome aberrations simultaneously with comprehensive chromosome screening in human preimplantation embryos for recurrent pregnancy loss. Journal of Assisted Reproduction and Genetics 2018 January 2018, Volume 35, Issue 1, pp 171–176 Impact factor: 2.788
53.Lai GL, Yeh CC, Yeh CY, Chen RY, Fu CL, Chen CH, Tzeng CR Decreased zinc and increased lead blood levels are associated with endometriosis in Asian Women. Reprod Toxicol. 2017 Sep 7;74:77-84 Impact factor: 2.341
54. *Chen CH (第一作者), Tzeng CR, Wang PH, Liu WM, Chang HY, Chen HH, Chen CH. Dual Triggering with GnRH Agonist plus hCG versus Triggering with hCG Alone for IVF/ICSI Outcome in GnRH Antagonist Cycles : a Systematic Review and Meta-Analysis. Archives of Gynecology and Obstetrics 2018 Mar 29. doi: 10.1007/s00404-018-4751-3 Impact factor: 2.236
55. An-Chieh Liu A, Chen CH, Liu WM, Chang CW. A rare Krukenberg tumor arising from a primary adenocarcinoma of the small intestine. Taiwan J Obstet Gynecol. 2018 Apr;57(2):319-322. doi: 10.1016/j.tjog.2018.02.025.
56. Chung MT, Tzeng CR, Chen CH, Chan C, Chang YE, Wu YH, Chen CH (責任作者). Live euploid birth and complete hydatid mole, followed by partial hydatid mole after ICSI. J Assist Reprod Genet. 2018 Jun 2. doi: 10.1007/s10815-018-1224-3. [Epub ahead of print]. Impact factor: 2.788
